mendeley

    Repaglinide-Indinavir Pharmacokinetic and Pharmacodynamic Interaction: Non-Clinical Evaluation in Hepatic and Diabetic Impairment models

    DOI Logo 10.17352/ijpsdr.000059

    Published On: April 14, 2026 | Pages: 009 - 016

    Author(s): Jeevan Karthik M, Aakarsha T, Lokesh J, Manaswini C, Rameshbabu J and Srinivas M*
    Background: Repaglinide, used for postprandial glucose control, is extensively metabolized by cytochrome P450 enzymes and transported by OATP and P-glycoprotein, making it susceptible to pharmacokinetic interactions. Indinavir, an antiviral protease inhibitor, affects metabolic and transport pathways, thereby altering the pharmacokinetic and pharmacodynamic profile of ... CrossMark Publons Harvard Library HOLLIS Search IT Semantic Scholar Get Citation Base Search Scilit OAI-PMH ResearchGate Academic Microsoft GrowKudos Universite de Paris UW Libraries SJSU King Library SJSU King Library NUS Library McGill DET KGL BIBLiOTEK JCU Discovery Universidad De Lima WorldCat VU on WorldCat
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    mendeley

    Application of the Gradient Descent Method for Optimization of Spin System Parameters of Metabolite Molecules by NMR Spectra

    DOI Logo 10.17352/ijpsdr.000058

    Published On: January 31, 2026 | Pages: 001 - 008

    Author(s): MM Fattakhov, DR Safin*, DA Fedorov, ES Khramov, ER Verevkin, AM Perepukhov and Yu M Belousov
    Nuclear Magnetic Resonance Spectroscopy is an effective physical method for metabolite fingerprinting, which involves the simultaneous and extensive analysis of a wide variety of compounds. The main disadvantage of the method, which hinders the progress of NMR metabolomics, is the need for manual processing of complex NMR spectra of biological samples. To automate the ... CrossMark Publons Harvard Library HOLLIS Search IT Semantic Scholar Get Citation Base Search Scilit OAI-PMH ResearchGate Academic Microsoft GrowKudos Universite de Paris UW Libraries SJSU King Library SJSU King Library NUS Library McGill DET KGL BIBLiOTEK JCU Discovery Universidad De Lima WorldCat VU on WorldCat
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