Metabolism of xenobiotics can be influenced by a number of factors, among which hyperglycaemia caused by the insufficiency of the glucose metabolism (e.g., diabetes mellitus, impaired glucose tolerance, resistance) should be emphasized. Not only the pathological condition, but the compounds administered as treatment can alter the metabolic profile of certain pharmacons. While the rapid-acting insulin exerts its effect mainly with the acute change of the blood glucose level, the prolonged-acting insulin affects in a more complex way.
Because of its simple and well-characterised metabolic profile, the p-nitrophenol (PNP) is a model compound for the investigation of conjugative (glucuronidation and sulfation) transformations.
An in vivo experimental study was evaluated to determine the quantities of the forming p – p-nitrophenyl-glucuronide (PNP-G) and p-nitrophenol-sulfate (PNP-S) conjugates in small intestinal perfusate and bile samples in physiologic condition, in experimental diabetes (streptozotocine (STZ) induced), and in compensated diabetes with prolonged–acting insulin. In these investigations, the formed metabolic profile was influenced by the individual effect of the administered insulin.
Keywords:
Published on: Sep 23, 2025 Pages: 14-19
Full Text PDF
Full Text HTML
DOI: 10.17352/ojpp.000027
CrossMark
Publons
Harvard Library HOLLIS
Search IT
Semantic Scholar
Get Citation
Base Search
Scilit
OAI-PMH
ResearchGate
Academic Microsoft
GrowKudos
Universite de Paris
UW Libraries
SJSU King Library
SJSU King Library
NUS Library
McGill
DET KGL BIBLiOTEK
JCU Discovery
Universidad De Lima
WorldCat
VU on WorldCat
PTZ: We're glad you're here. Please click "create a new query" if you are a new visitor to our website and need further information from us.
If you are already a member of our network and need to keep track of any developments regarding a question you have already submitted, click "take me to my Query."